Table 1.
Summary of JAKs and corresponding STATs as well as cytokines.
| JAKs | Associated STATs | Associated cytokines |
|---|---|---|
| JAK2 | STAT1, STAT3, STAT5 | IL-5, GH |
| JAK2 | STAT3 | Leptin |
| JAK2 | STAT5 | GM-CSF, EPO, PRL, TPO |
| JAK1, JAK2 | STAT1 | IFN-γ |
| JAK1, JAK2 | STAT3 | G-CSF |
| JAK1, JAK2 | STAT1, STAT3 | CLCF, IL-19, IL-20, IL-24/mda7 |
| JAK1, JAK2 | STAT1, STAT3, STAT5 | IL-31 |
| JAK1, JAK2 | STAT1, STAT4 | IL-35 (p35 + EBI3) |
| JAK1, JAK2 | STAT1, STAT3, STAT4, STAT5, STAT6 | TSLP |
| JAK1, JAK2 | STAT3, STAT5 | IL-3 |
| JAK1, JAK2, TYK2 | STAT3 | CT-1 |
| JAK1, JAK2, TYK2 | STAT1, STAT3 | IL-6, IL-11, LIF, OSM, CNTF |
| JAK1, JAK2, TYK2 | STAT3, STAT6 | IL-13 |
| JAK1, JAK2, TYK2 | STAT1, STAT3, STAT4, STAT5 | IL-27 (p28 + EBI3) |
| JAK1, JAK3 | STAT3, STAT5 | IL-7, IL-2, IL-9, IL-15, IL-21 |
| JAK1, JAK3 | STAT6 | IL-4 |
| JAK1, TYK2 | STAT1, STAT2, STAT3, STAT5 | IL-20, IL-22, IL-28a, IL-28b, IL29 |
| JAK1, TYK2 | STAT1, STAT3 | IL-10, IL-26/AK155 |
| JAK1, TYK2 | STAT1, STAT3, STAT5 | IL-22/IL-TIF |
| JAK1, TYK2 | STAT1, STAT2, STAT3, STAT4, STAT5, STAT6 | IFN-α, IFN-β |
| TYK2, JAK2 | STAT4 | IL-12 (p35 + p40) |
| TYK2, JAK2 | STAT1, STAT3, STAT4 | IL-23 (p19 + p40) |
GH = growth hormone; GM-CSF = granulocyte–macrophage colony stimulating factor; EPO = erythropoietin; PRL = prolactin; TPO = thrombopoietin; IFN = interferon; G-CSF = granulocyte colony stimulating factor; IL = interleukin; CT-1 = cardiotrophin-1; CLCF1 = recombinant cardiotrophin like cytokine factor 1; TSLP = recombinant human thymic stromal lymphopoietin; OSM = ontostatin M; CNTF = ciliary neurotrophic factor.