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The X-ray crystal structure of SARS-CoV PLpro (A-1) and SARS-CoV-2 PLpro (B-1), and their shallow active sites at a similar location on the protein surface (graphic images prepared by Molegro Molecular Viewer 6.5 software); A-2 and B-2: X-ray co-crystal structures of SARS-CoV PLpro (A-2, PDB code: 3E9S) and SARS-CoV-2 PLpro (B-2, PDB code: 7CMD) bonded with well-known inhibitor GRL0617 (graphic images were analyzed by Discovery Studio Visualizer v4.5.).
