Fig. 3.
A) The PEG-lipids used in Onpattro® (PEG-c-DMG) and the COVID-19 vaccine LNP products Spikevax® (PEG-DMG) and Comirnaty® (ALC-0159). B) Additional PEG-lipids discussed in this Review. C) The proposed uptake mechanism for Onpattro® [56]. The figure was created with BioRender.com. D) Cryo-TEM images of LNPs with varying molar ratios of PEG-lipid. Reproduced from [52] with permission from the Royal Society of Chemistry.