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. 2022 Jul 3;188:114416. doi: 10.1016/j.addr.2022.114416

Fig. 3.

Fig. 3

A) The PEG-lipids used in Onpattro® (PEG-c-DMG) and the COVID-19 vaccine LNP products Spikevax® (PEG-DMG) and Comirnaty® (ALC-0159). B) Additional PEG-lipids discussed in this Review. C) The proposed uptake mechanism for Onpattro® [56]. The figure was created with BioRender.com. D) Cryo-TEM images of LNPs with varying molar ratios of PEG-lipid. Reproduced from [52] with permission from the Royal Society of Chemistry.