Table 11.
Inhibition activity of isothiazolo [4,3-b]pyridine analogs against GAK.
Heterocyclic Scaffolds | Kd (μM) | Heterocyclic Scaffolds | Kd (μM) |
---|---|---|---|
![]() |
0.052 | ![]() |
2 |
![]() |
0.77 | ![]() |
>30 |
![]() |
0.52 | ![]() |
0.041 |
![]() |
0.86 | ![]() |
>30 |
![]() |
0.4 | ![]() |
7.6 |
![]() |
>30 | ![]() |
3.2 |
Inhibition activity of isothiazolo [4,3-b]pyridine analogs against GAK.
Heterocyclic Scaffolds | Kd (μM) | Heterocyclic Scaffolds | Kd (μM) |
---|---|---|---|
![]() |
0.052 | ![]() |
2 |
![]() |
0.77 | ![]() |
>30 |
![]() |
0.52 | ![]() |
0.041 |
![]() |
0.86 | ![]() |
>30 |
![]() |
0.4 | ![]() |
7.6 |
![]() |
>30 | ![]() |
3.2 |