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Optimized structures of a few pyrazine-2,3-dicarboxamide exhibiting DENV inhibitions.
| Compound No. | Heterocyclic Scaffolds | EC50 | CC50 | SI |
|---|---|---|---|---|
| 79 |  |
26.5 | >116 | >4 |
| 80 |  |
0.5 | >117 | >235 |
| 81 |  |
4.6 | >116 | >25 |
| 82 |  |
0.5 | >117 | >235 |
| 83 |  |
2.2 | >120 | >55 |
| 84 |  |
3.4 | 24 | 7 |
| 85 |  |
2.1 | >116 | >55 |
| 86 |  |
<0.9 | 26 | >29 |
