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Inhibition activity and binding scores of the S-alkylated and S-alkylphthalimidated analogs against the DENV-2.
| Compound No. | Heterocyclic Scaffolds | % Inhibition of DENV2 | IC50 (μM) | Docking Score (kcal/mol) |
|---|---|---|---|---|
| 158 |  |
99.9 ± 1.3 | 13.9 ± 1.4 | −9.0 |
| 159 |  |
77.6 ± 2.1 | 15.1 ± 1.3 | −8.8 |
| 160 |  |
83.9 ± 1.3 | 25.2 ± 1.2 | −8.6 |
| 161 |  |
80.4 ± 1.7 | 23.9 ± 1.2 | −8.6 |
| 162 |  |
80.8 ± 1.0 | 24.0 ± 1.6 | −8.6 |
