Table 34.

Comprehensive SAR of the reported N, S-heterocyclic scaffolds.

N, S-Heterocyclic Scaffold	SARs	Key Highlights	References
Thiazoles or Benzothiazoles		•Inhibits DENV2 NS2B/NS3 protease. •Ortho-substitution displays greater inhibition as compared to the para-substitution.	[183]
		•Inhibits DENV2. •Various substituents present on the phenyl ring of the truncated benzothiazole scaffolds affect greater inhibition. •The absence of any substituent decreases the inhibition rate.	[184]
Thiazolidinones		•DENV-2 NS5 RdRp polymerase. •Modulation of various substituents on R1 and R2 affects the inhibition activity.	[190]
Benzothiazines		•Inhibits DENV3 NS5 RdRp. •R1 and R2 contribute significantly to the inhibition of DENV3 NS5 RdRp. •Strongly electron-donating and electron-withdrawing groups tend to decrease the inhibition. •The o- or m-substitution at R3 plays a significant role in the inhibition.	[195]