Table 35.

Comprehensive SAR of the reported N, O-heterocyclic scaffolds.

N, O-Heterocyclic Scaffold	SARs	Key Highlights	References
Oxadiazole		•Inhibits DENV2 RdRp •The existence of chlorine on the thiophene ring plays a contribution to the inhibition activity •The existence of chlorine substituents at the p-position enhanced the inhibition activity while chlorine at the m-position decreased the inhibition activity •The p-substituents on the phenyl ring and bromo-substituent on the thiophene are in a vital position.	[15]
		•Suppress the larvicidal and adulticidal activity of several Aedes aegypti mosquitoes. •The nitro (–NO2), bromo (-Br), and chloro (-Cl) substituents showed a greater mortality rate. •The fluoro-substituent decreased the mortality rate.	[202]
		•Inhibits DENV2. •The length of the alkyl chain and the substituents on the phenyl ring are the most contributing factors to the inhibition. •The presence of –CH3 on the phenyl ring causes a decrease in the inhibition while –CF3 enhances the inhibition rate.	[203]
		•Inhibits DENV2. •The presence of halogens forms H-bond which causes greater binding affinity.	[204]