Table 6.
Table showing the cytotoxicity values and anti-dengue activity of selected diarylpyrazolylquinoline scaffolds.
Compound No. | Heterocyclic Scaffolds | %Inhibition of DENV2 |
%Cell Viability of Huh-7 cell |
||
---|---|---|---|---|---|
1 μM | 10 μM | 20 μM | 200 μM | ||
28 | ![]() |
5.21 3.1 | 15.31 2.3 | 124.10 7.48 | 115.31 11.43 |
29 | ![]() |
3.58 1.7 | 6.14 2.1 | 88.26 9.46 | 89.72 1.71 |
30 | ![]() |
4.14 2.3 | 7.15 1.9 | 95.56 5.07 | 93.68 5.75 |
31 | ![]() |
3.02 1.8 | 5.13 1.4 | 125.54 6.35 | 98.29 7.59 |
32 | ![]() |
11.23 2.8 | 25.39 3.4 | 88.13 1.84 | 87.49 7.61 |
33 | ![]() |
5.31 1.6 | 8.09 2.3 | 103.99 3.75 | 98.90 9.26 |
34 | ![]() |
4.36 1.7 | 8.31 1.5 | 97.82 3.68 | 91.56 3.85 |
35 | ![]() |
8.91 1.3 | 22.35 1.7 | 95.32 2.61 | 86.51 4.51 |
36 | ![]() |
41.42 2.4 | 55.32 1.8 | 98.75 2.87 | 95.37 3.64 |
37 | ![]() |
7.81 2.5 | 20.68 1.8 | 115.73 3.28 | 97.35 8.21 |
38 | ![]() |
6.12 2.1 | 15.83 3.2 | 89.08 8.16 | 52.55 1.89 |
39 | ![]() |
46.87 5.3 | 65.71 4.1 | 95.81 4.82 | 98.40 16.44 |
40 | ![]() |
4.52 2.7 | 11.81 1.9 | 89.22 4.03 | 83.64 2.68 |
41 | ![]() |
5.71 1.7 | 12.75 1.8 | 91.12 2.04 | 42.97 2.47 |
42 | ![]() |
58.96 2.8 | 85.34 6.7 | 83.71 2.52 | 89.53 2.41 |