Table 2. Associations between obesity, MetS, and the risk of endometrial cancer.
| BMI, metabolic phenotype | No. participants | Person-years | No. cases | HR (95% CI)* | p-value | HR (95% CI)† | p-value | HR (95% CI)‡ | p-value | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI (kg/m2) | |||||||||||
| <23 | 2,649,564 | 23,964,689.4 | 2,253 | 1 | |||||||
| 23–25 | 1,507,663 | 13,124,206.3 | 1,650 | 1.36 (1.28–1.45) | <0.001 | ||||||
| ≥25 | 1,940,459 | 16,863,092.8 | 2,894 | 1.92 (1.82–2.04) | <0.001 | ||||||
| MetS | |||||||||||
| No | 4,599,874 | 40,029,489.5 | 4,810 | 1 | 1 | ||||||
| Yes | 1,497,812 | 13,022,499.0 | 1,987 | 1.44 (1.36–1.52) | <0.001 | 1.42 (1.34–1.50) | <0.001 | ||||
| Per 1 increment component of MetS | - | - | 1.17 (1.15–1.20) | <0.001 | 1.17 (1.15–1.19) | <0.001 | |||||
| Component of MetS | |||||||||||
| Elevated BP | |||||||||||
| No | 3,930,473 | 34,198,779.3 | 4,220 | 1 | 1 | 1 | |||||
| Yes | 2,167,213 | 18,853,209.2 | 2,577 | 1.22 (1.16–1.82) | <0.001 | 1.21 (1.15–1.27) | <0.001 | 1.13 (1.07–1.19) | <0.001 | ||
| Elevated FBG | |||||||||||
| No | 4,324,091 | 37,644,549.6 | 4,650 | 1 | 1 | 1 | |||||
| Yes | 1,773,595 | 15,407,438.8 | 2,147 | 1.19 (1.13–1.26) | <0.001 | 1.18 (1.12–1.25) | <0.001 | 1.10 (1.05–1.16) | <0.001 | ||
| High WC | |||||||||||
| No | 3,636,723 | 31,656,013.0 | 3,554 | 1 | 1 | 1 | |||||
| Yes | 2,460,963 | 21,395,975.5 | 3,243 | 1.52 (1.45–1.60) | <0.001 | 1.49 (1.42–1.57) | <0.001 | 1.43 (1.36–1.51) | <0.001 | ||
| Elevated TG | |||||||||||
| No | 4,679,785 | 40,706,563.9 | 5,042 | 1 | 1 | 1 | |||||
| Yes | 1,417,901 | 12,345,424.6 | 1,755 | 1.23 (1.17–1.30) | <0.001 | 1.22 (1.16–1.29) | <0.001 | 1.10 (1.03–1.16) | 0.002 | ||
| Reduced HDL | |||||||||||
| No | 4,257,796 | 37,025,479.4 | 4,549 | 1 | 1 | 1 | |||||
| Yes | 1,839,890 | 16,026,509.1 | 2,248 | 1.17 (1.12–1.24) | <0.001 | 1.18 (1.12–1.24) | <0.001 | 1.09 (1.04–1.15) | 0.001 | ||
BMI, body mass index; BP, blood pressure; CI, confidence interval; FBG, fasting blood glucose; HDL, high-density lipoprotein; HR, hazard ratio; MetS, metabolic syndrome; TG, triglyceride; WC, waist circumference.
*Adjusted for age, smoking, drinking, vigorous physical activity, moderate physical activity, walking, age at menarche, age at menopause, number of children, breast feeding, oral contraceptive use, and family history of cancer; †Adjusted for the variables mentioned above and BMI; ‡Adjusted for the other components of MetS.