Table 4. HR and 95% CI of the combined association of MetS, obesity and the risk of endometrial cancer.
| Variables | BMI (kg/m2) | No. participants | Person-years | No. cases | HR* (95% CI) | p-value | |
|---|---|---|---|---|---|---|---|
| MeS | |||||||
| No | <23 | 2,415,963 | 21,028,271.6 | 2,067 | 1 | ||
| 23–25 | 1,143,111 | 9,949,836.8 | 1,287 | 1.37 (1.27–1.46) | <0.001 | ||
| ≥25 | 1,040,800 | 9,051,381.1 | 1,456 | 1.75 (1.64–1.87) | <0.001 | ||
| Yes | <23 | 233,601 | 2,036,417.8 | 186 | 1.13 (0.97–1.32) | 0.111 | |
| 23–25 | 364,552 | 3,174,369.5 | 363 | 1.38 (1.23–1.55) | <0.001 | ||
| ≥25 | 899,659 | 7,811,711.7 | 1,438 | 2.18 (2.03–2.34) | <0.001 | ||
| Elevated BP | |||||||
| No | <23 | 1,988,840 | 17,306,485.3 | 1,725 | 1 | ||
| 23–25 | 957,264 | 8,332,062.0 | 1,108 | 1.40 (1.29–1.51) | <0.001 | ||
| ≥25 | 984,369 | 8,560,231.9 | 1,387 | 1.76 (1.64–1.89) | <0.001 | ||
| Yes | <23 | 660,724 | 5,758,204.1 | 528 | 1.05 (0.95–1.16) | 0.319 | |
| 23–25 | 550,399 | 4,792,144.3 | 542 | 1.32 (1.19–1.45) | <0.001 | ||
| ≥25 | 956,090 | 8,302,860.9 | 1,507 | 2.13 (1.98–2.29) | <0.001 | ||
| Elevated FBG | |||||||
| No | <23 | 2,073,820 | 18,054,351.6 | 1,788 | 1 | ||
| 23–25 | 1,062,974 | 9,257,278.9 | 1,150 | 1.32 (1.22–1.42) | <0.001 | ||
| ≥25 | 1,877,297 | 10,332,919.1 | 1,712 | 1.81 (1.69–1.94) | <0.001 | ||
| Yes | <23 | 575,744 | 5,010,337.8 | 465 | 1.01 (0.91–1.12) | 0.825 | |
| 23–25 | 444,689 | 3,866,927.4 | 500 | 1.45 (1.32–1.61) | <0.001 | ||
| ≥25 | 753,162 | 6,530,173.6 | 1,182 | 2.08 (1.93–2.24) | <0.001 | ||
| High WC | |||||||
| No | <23 | 2,392,369 | 20,824,185.1 | 2,024 | 1 | ||
| 23–25 | 896,336 | 7,803,106.0 | 1,051 | 1.42 (1.31–1.53) | <0.001 | ||
| ≥25 | 348,018 | 3,028,721.9 | 479 | 1.66 (1.50–1.84) | <0.001 | ||
| Yes | <23 | 257,195 | 2,240,504.3 | 229 | 1.23 (1.07–1.41) | 0.003 | |
| 23–25 | 611,327 | 5,321,100.3 | 599 | 1.32 (1.20–1.45) | <0.001 | ||
| ≥25 | 1,592,441 | 13,834,370.9 | 2,415 | 2.02 (1.90–2.15) | <0.001 | ||
| Elevated TG | |||||||
| No | <23 | 2,263,454 | 19,698,543.4 | 1,941 | 1 | ||
| 23–25 | 1,132,443 | 9,854,374.7 | 1,260 | 1.36 (1.27–1.46) | <0.001 | ||
| ≥25 | 1,283,888 | 11,153,645.8 | 1,841 | 1.82 (1.70–1.94) | <0.001 | ||
| Yes | <23 | 386,110 | 3,366,146.0 | 312 | 1.06 (0.94–1.19) | 0.361 | |
| 23–25 | 375,220 | 3,269,831.6 | 390 | 1.37 (1.26–1.53) | <0.001 | ||
| ≥25 | 656,571 | 5,709,447.0 | 1,053 | 2.14 (1.98–2.31) | <0.001 | ||
| Reduced HDL | |||||||
| No | <23 | 2,020,563 | 17,575,636.9 | 1,717 | 1 | ||
| 23–25 | 1,023,987 | 8,908,487.7 | 1,093 | 1.32 (1.22–1.42) | <0.001 | ||
| ≥25 | 1,213,246 | 10,541,354.7 | 1,739 | 1.84 (1.72–1.97) | <0.001 | ||
| Yes | <23 | 629,001 | 5,489,052.5 | 536 | 1.05 (0.96–1.16) | 0.303 | |
| 23–25 | 483,676 | 4,215,718.6 | 557 | 1.47 (1.34–1.62) | <0.001 | ||
| ≥25 | 727,213 | 6,321,738.1 | 1,155 | 2.08 (1.93–2.25) | <0.001 | ||
BP, blood pressure; CI, confidence interval; FBG, fasting blood glucose; HDL, high-density lipoprotein; HR, hazard ratio; MetS, metabolic syndrome; TG, triglyceride; WC, waist circumference.
*Adjusted for age, smoking, drinking, vigorous physical activity, moderate physical activity, walking, age at menarche, age at menopause, number of children, breast feeding, oral contraceptive use, and family history of cancer.