Table 2. Meta-analysis of clinical characteristics of patient with postoperative complication compared to patients without postoperative complication.
| Variable | No. of studies | No. of patients | Pooled OR or WMD (95% CI) | p-value from random effects model | I2 index (%) | Egger’s p-value | |
|---|---|---|---|---|---|---|---|
| Total | 15 | 15,325 | |||||
| Clinical characteristic | |||||||
| Age | 7 | 6,175 | 4.08 (2.58–5.58) | <0.001 | 34.40 | 0.420 | |
| Age ≥60 yr | 4 | 875 | 1.93 (1.35–2.76) | <0.001 | 15.10 | 0.385 | |
| BMI | 3 | 470 | 1.42 (0.81–3.64) | 0.212 | 73.46 | 0.956 | |
| ECOG performance score >0 | 3 | 434 | 1.95 (1.29–2.94) | 0.001 | 0.00 | 0.485 | |
| ASA classification score >1 | 3 | 321 | 0.98 (0.21–4.47) | 0.976 | 72.00 | 0.702 | |
| Comorbidity | 7 | 1,848 | 2.06 (1.09–3.90) | 0.026 | 78.80 | 0.342 | |
| Presence of ascites | 4 | 841 | 2.75 (1.48–5.11) | 0.001 | 62.00 | 0.540 | |
| FIGO stage IV | 6 | 7,061 | 1.56 (1.29–1.89) | <0.001 | 16.62 | 0.301 | |
| NACT-IDS | 2 | 815 | 0.44 (0.28–0.70) | <0.001 | 0.00 | - | |
| Procedure | |||||||
| Diaphragmatic peritonectomy | 6 | 1,202 | 1.67 (0.93–3.00) | 0.083 | 42.20 | 0.007 | |
| Peritonectomy | 2 | 141 | 3.55 (1.33–9.49) | 0.012 | 0.00 | - | |
| Splenectomy | 4 | 939 | 4.47 (2.79–7.17) | <0.001 | 0.00 | 0.312 | |
| Liver surgery | 3 | 783 | 10.04 (0.95–105.74) | 0.055 | 91.54 | 0.385 | |
| Colon surgery | 4 | 1,061 | 4.24 (2.87–6.28) | <0.001 | 0.00 | 0.879 | |
| Extensive surgery* | 8 | 6,988 | 2.67 (1.69–4.22) | <0.001 | 77.37 | 0.793 | |
| Blood transfusion | 2 | 223 | 4.09 (0.73–23.00) | 0.110 | 82.00 | - | |
| Post-operative outcome | |||||||
| No gross residual tumor | 2 | 351 | 1.09 (0.65–1.85) | 0.700 | 0.00 | - | |
| Serous carcinoma | 4 | 1,519 | 1.26 (0.66–2.39) | 0.478 | 74.54 | 0.003 | |
| High-graded histology | 2 | 652 | 0.98 (0.28–3.44) | 0.978 | 78.90 | - | |
ASA, American Society of Anesthesiologists; BMI, body mass index; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; FIGO, International Federation of Gynecology and Obstetrics; NACT-IDS, neoadjuvant chemotherapy followed by interval debulking surgery; OR, odds ratio; WMD, weighted mean difference.
*Extensive surgery: additional surgery included one of the following procedures: bowel resection, splenectomy, pelvic peritonectomy, diaphragm peritonectomy or extra abdominal tumor debulking.