Table 3. Primary outcomes by surgical and BRCA mutation status.
| Outcomes | BRCA mutation with RRBSO (n=329) | BO without BRCA mutation (n=3,290) | 95% CI | BRCA mutation with RRBSO (n=329) | Intact ovaries without BRCA mutation (n=3,290) | 95% CI | |
|---|---|---|---|---|---|---|---|
| Bone fractures | |||||||
| Persons-years | 2,415.4 | 31,235.9 | - | 2,415.4 | 28,291.0 | - | |
| No. of events | 44 | 616 | - | 44 | 445 | - | |
| Crude HR | 0.96 | 1 | 0.71–1.31 | 1.21 | 1 | 0.89–1.65 | |
| Adjusted HR* | 0.80 | 1 | 0.56–1.14 | 1.02 | 1 | 0.65–1.61 | |
| Osteoporosis | |||||||
| Persons-years | 2,534.0 | 34,307.4 | - | 2,534.0 | 30,780.4 | - | |
| No. of events | 22 | 127 | - | 22 | 45 | - | |
| Crude HR | 2.64 | 1 | 1.67–4.17 | 7.42 | 1 | 4.39–12.55 | |
| Adjusted HR* | 1.83 | 1 | 1.03–3.26 | 6.38 | 1 | 3.11–13.08 | |
| No. of women who had DEXA scan | 152 | 761 | 152 | 335 | |||
| Osteoporosis | |||||||
| Persons-years | 1,304.8 | 9,542.6 | - | 1,304.8 | 4,542.1 | - | |
| No. of events | 22 | 108 | - | 22 | 38 | - | |
| Crude HR | 1.60 | 1 | 1.00–2.54 | 2.54 | 1 | 1.47–4.39 | |
| Adjusted HR† | 1.60 | 1 | 1.00–2.54 | 2.49 | 1 | 1.44–4.28 | |
RRBSO, risk-reducing bilateral salpingo-oophorectomy; BO, bilateral oophorectomy; CI, confidence interval; HR, hazard ratio; DEXA, dual-energy X-ray absorptiometry.
*Adjusted for history breast cancer; †Adjusted for age at surgery.