Table 2. Characteristics of patients with and without p53 signatures.
Characteristics | RRSO patients (n=13) | Control patients (n=17) | |||||
---|---|---|---|---|---|---|---|
p53 signature (n=7) | No p53 signature (n=6) | p-value | p53 signature (n=6) | No p53 signature (n=11) | p-value | ||
Mean age at operation (yr) | 49.4 | 47.3 | 0.57* | 49 | 44.9 | 0.11* | |
BMI (mean) | 20.95 | 21.03 | 0.95* | 22.97 | 21.83 | 0.48* | |
Parity | 0.9* | 0.9† | |||||
Nulliparous | 1 | 1 | 4 | 7 | |||
Parous | 6 | 5 | 2 | 4 | |||
Hormone therapy for breast cancer | 0.85† | ||||||
No | 5 | 4 | |||||
Yes | 2 | 2 | |||||
GnRH analog | 0.11† | ||||||
No | 2 | 8 | |||||
Yes | 4 | 3 | |||||
OC use | - | - | |||||
Never | 7 | 6 | 6 | 11 | |||
Ever | 0 | 0 | 0 | 0 | |||
Race | - | - | |||||
Asian | 7 | 6 | 6 | 11 | |||
BRCA1/2 pathogenic variant | 0.053† | NA | |||||
BRCA1 | 6 | 2 | |||||
BRCA2 | 1 | 4 |
NA, not available.
*t-test; †χ2 test.