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. 2022 Jun 20;22(3):e21. doi: 10.4110/in.2022.22.e21

Figure 3. Multitasking roles of SIRT1 through the downstream signaling pathways mediated by HMGB1. The multitasking roles of SIRT1 are shown in regulating antimicrobial effect, inflammatory responses, antiviral effect, autophagy, and mitochondrial function through the downstream signaling pathways mediated by HMGB1.

Figure 3

CR, caloric restriction.