Figure 4. Regulatory effects verification of SIRT1 by activators or inhibitors injection. The regulatory effects of several SIRT1 activators and inhibitors are shown. Quercetin (an activator of SIRT1) suppresses NLRP3 inflammasome in COVID-19. Berberine (an activator of SIRT1) promotes the autophagy of peritoneal macrophages. SRT2183 (an activator of SIRT1) induces autophagy in ovarian cancer cells. SRT1720 (an activator of SIRT1) notably decreases collagen deposition in the mice kidneys. Salermide (an inhibitor of SIRT1) induces autophagy in human NSCLC cells. EX-527 (an inhibitor of SIRT1) suppresses the proliferation and colony formation ability of human glioma cells.
