| Activator |
Resveratrol |
Increase mitophagy |
Osteoporosis rats |
(69) |
| Quercetin |
Suppress NLRP3 inflammasome |
COVID-19 |
(70) |
| Berberine |
Promote autophagy of peritoneal macrophages |
Atherosclerosis |
(73) |
| Metformin |
Activate autophagy, mitigates cartilage degradation |
Mouse osteoarthritis |
(74) |
| Melatonin |
Regulate apoptosis and autophagy |
Sepsis-induced cardiac dysfunction |
(75) |
| SRT1720 |
Partially attenuate fibrosis and apoptosis |
Fibrotic kidney disease |
(72) |
| SRT1460 |
Weaken oxidative stress |
Myocardial ischemia/reperfusion injury |
(71) |
| SRT2183 |
Induce autophagy |
Ovarian cancer cells |
(76) |
| Inhibitor |
EX-527 |
Induced cell apoptosis |
Glioma |
(77) |
| Tenovin-1 |
Induce a nonlinear apoptosis-inducing factor-dependent cell death |
p53 null Ewing’s sarcoma cell line |
(78) |
| Tenovin-6 |
Induced apoptosis and cell cycle arrest |
Primary effusion lymphoma |
(79) |
| Cambinol |
Inhibit proliferation and induce apoptosis |
Myeloma cell lines |
(80) |
| Sirtinol |
Protect the allograft from inflammatory cell infiltration |
Mouse cervical heterotopic heart transplantation |
(81) |
| Salermide |
Induce autophagy in human NSCLC cells |
NSCLC |
(82) |
| Splitomicin |
Enhance the yield of specific hematopoietic lineage cells from embryonic stem cells |
Hematopoietic differentiation of embryonic stem cells |
(83) |
| NAM |
Increase the sensitivity of chronic myeloid leukemia to doxorubicin |
Chronic myeloid leukemia |
(84) |
