Table 2.
Absolute risks and numbers needed to treat by week of gestation in the ALPS cohort, re-weighted to reflect the gestational age distribution at maternal admission for delivery of a population-based sample within the late preterm period from British Columbia, Canada, 2000–2013.
Outcome | Data | Gestational age | Antenatal corticosteroids risk per 100 | Placebo risk per 100 | Absolute risk per 100 (95% confidence interval) | Number Needed to Treat |
---|---|---|---|---|---|---|
| ||||||
Primary outcome | Original ALPS | 34 weeks | 19.3 | 23.3 | −4.1 (−8.1, 0.1) | 24 |
Original ALPS | 35 weeks | 11.2 | 13.6 | −2.4 (−4.7, 0.0) | 42 | |
Original ALPS | 36 weeks | 6.6 | 7.9 | −1.4 (−2.8, 0.0) | 72 | |
ALPS re-weighted | 34 weeks | 19.7 | 23.4 | −3.7 (−7.9, 0.5) | 27 | |
ALPS re-weighted | 35 weeks | 11.1 | 13.2 | −2.1 (−4.4, 0.3) | 48 | |
ALPS re-weighted | 36 weeks | 6.3 | 7.5 | −1.2 (−2.5, 0.1) | 84 | |
Major respiratory morbidity | Original ALPS | 34 weeks | 13.8 | 20.2 | −6.4 (−10.1, −2.3) | 16 |
Original ALPS | 35 weeks | 7.6 | 11.1 | −3.6 (−5.6, −1.5) | 28 | |
Original ALPS | 36 weeks | 5.2 | 6.2 | −2.0 (−3.2, −0.7) | 51 | |
ALPS re-weighted | 34 weeks | 13.9 | 20.4 | −6.5 (−10.1, −2.1) | 15 | |
ALPS re-weighted | 35 weeks | 7.4 | 10.9 | −3.5 (−5.5, −1.1) | 29 | |
ALPS re-weighted | 36 weeks | 4.0 | 5.8 | −1.9 (−3.2, −0.6) | 54 |