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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Paediatr Perinat Epidemiol. 2022 Jan 4;37(1):1–8. doi: 10.1111/ppe.12856

Table 2.

Absolute risks and numbers needed to treat by week of gestation in the ALPS cohort, re-weighted to reflect the gestational age distribution at maternal admission for delivery of a population-based sample within the late preterm period from British Columbia, Canada, 2000–2013.

Outcome Data Gestational age Antenatal corticosteroids risk per 100 Placebo risk per 100 Absolute risk per 100 (95% confidence interval) Number Needed to Treat

Primary outcome Original ALPS 34 weeks 19.3 23.3 −4.1 (−8.1, 0.1) 24
Original ALPS 35 weeks 11.2 13.6 −2.4 (−4.7, 0.0) 42
Original ALPS 36 weeks 6.6 7.9 −1.4 (−2.8, 0.0) 72
ALPS re-weighted 34 weeks 19.7 23.4 −3.7 (−7.9, 0.5) 27
ALPS re-weighted 35 weeks 11.1 13.2 −2.1 (−4.4, 0.3) 48
ALPS re-weighted 36 weeks 6.3 7.5 −1.2 (−2.5, 0.1) 84
Major respiratory morbidity Original ALPS 34 weeks 13.8 20.2 −6.4 (−10.1, −2.3) 16
Original ALPS 35 weeks 7.6 11.1 −3.6 (−5.6, −1.5) 28
Original ALPS 36 weeks 5.2 6.2 −2.0 (−3.2, −0.7) 51
ALPS re-weighted 34 weeks 13.9 20.4 −6.5 (−10.1, −2.1) 15
ALPS re-weighted 35 weeks 7.4 10.9 −3.5 (−5.5, −1.1) 29
ALPS re-weighted 36 weeks 4.0 5.8 −1.9 (−3.2, −0.6) 54