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. 2022 Jan 4;43(1):79–97. doi: 10.1007/s10571-021-01179-z

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mice with inherited ocular hypertension (DBA/2J) were divided into non-ovariectomized controls (non-OVX), ovariectomized (OVX), and ovariectomized treated with systemic 17β-estradiol (OVX + E2). Here, C57BL/6J served as a control group. At 6 months, IOP was higher in DBA/2J mice in both non-OVX and OVX animals compared to C57BL/6J mice, with OVX animals having a significantly higher IOP compared to non-OVX animals (p < 0.05). Treatment with systemic 17β-estradiol significantly lowered IOP compared to OVX animals (p < 0.05).

Data were adapted from Zhou et al. (2007) and represented as mean ± SD