TABLE 1.

MiR-34a acts on various organ fibrosis.

Tissue	Species	Target	Mechanism	References
Liver	Rat, hepatocyte, mice, intrahepatic biliary epithelial cells, HSCs, human	SIRT1, p53; caspase2	apoptosis	Tian et al. (2016), Meng et al. (2012)
		ACSL1; PPAR-γ; RXRa	target genes	Yan et al. (2015); Yan. (2016), Oda et al. (2014);Li et al. (2015)
		Smad4, Smad3	TGF-β1/Smad pathway	Feili et al. (2018), Song et al. (2019)
		p16、p21、CCL2、PAI-1	Cellular senescence	Wan et al. (2017)
Kidney	Mice, rat, renal tubular epithelial cells, renal interstitial fibroblasts	Bcl-2	apoptosis	Zhou et al. (2014); Li et al. (2019)
		Klotho; Notch1	target genes	Liu et al. (2019), Du et al. (2012)
		SIRT1	autophagy	Xue et al. (2018), Zhu et al. (2019)
Heart	Rat, myocardial fibroblasts, mice	C-Ski; PNUTS	target genes	Zhang et al. (2018), Boon et al. (2013)
		Smad4	TGF-β1/smad pathway	Huang et al. (2014)
		PI3K/AKT	autophagy	Liu et al. (2018)
Lung	Human, mice, type II alveolar epithelial cells	SIRT1, p53	apoptosis	Shetty et al. (2017)
		nectin-1、Abca3	target genes	Takano et al. (2017)
		E2F1、c-Myc、CCNE2	Celluar senescence	Disayabutr et al. (2016); Cui et al. (2017b)
Skin	mice	c-Met	target genes	Simone et al. (2014)