TABLE 2.

the biological agents of miR-34a and related molecules for fibrosis.

Type	Biologics	Target	Tissue/Cell	References
miR-34a inhibitor	MiR-34a inhibitor	miR-34a	renal tubular epithelial cells, intrahepatic biliary epithelial cells, HSCs, hepatocyte, Cardiac fibroblasts, heart, liver, lung	Zhou et al. (2014), Yan et al. (2015), Li et al. (2015), Kim et al. (2015), Huang et al. (2014), Bernardo et al. (2016), Pan et al. (2021), Zhang et al. (2021a), Zhang et al. (2021b), Cui et al. (2017b)
	Hydrogen sulfide (H2S)		heart	Liu et al. (2018)
	Astragaloside-IV(AS-IVA)		cardiomyocytes	Zhu et al. (2019)
	Aqueous extract from Prunella Vulgaris (PVAE)		HSCs	Hu et al. (2016)
	Pterostilbene		hepatocyte	Song et al. (2019)
	Atorvastatin		endothelial cell	Tabuchi et al. (2012)
Preparation of miR-34a-related molecules	SRT1720	SIRT1	hepatocyte	Tian et al. (2016)
	Resveratrol	SIRT1	liver, kidney	Chávez et al. (2008); Hong et al. (2010); Li et al. (2010)
	pifithrin -α	p53	hepatocyte	Kim et al. (2015)
	PPARγ agonist	PPARγ	HSCs	Attia et al. (2013); Sharvit et al. (2013)
	Smad4 siRNA	Smad4	cardiac fibroblast	Huang et al. (2014)
	Jagged1 siRNAs	Jagged1	renal tubular epithelial cells	Du et al. (2012)
	Notch1siRNAs	Notch1	renal tubular epithelial cells	Du et al. (2012)
	LGR4 siRNA	LGR4	retinal pigment epithelial cells	Hou et al. (2016)
	PNUTS	PNUTS	heart	Boon et al. (2013)