TABLE 2.
Details of curcumin’s role in inflammatory bowel disease treatment in animal studies.
| Experimental colitis | Dose (mg/kg) | Duration | Effects on BW/DAI/cell apoptosis etc. a | Effects on biomarkers | Ref. |
|---|---|---|---|---|---|
| IL10−/− mice | 8–162 | 20 weeks | Survival rate↑ colon weight/length ratio↓ bacterial richness↑ age-related decrease in alpha diversity↓ the relative abundance of Lactobacillales↑ Coriobacterales order↓ | — | McFadden et al. (2015) |
| TNF-α-induced colitis in mice | 25 | 6.5 h | colon oxidative stress and neutrophils influx↓ cell apoptosis↓ macroscopic and microscopic colon damage scores↓ | MPO↓MDA↓ | Mouzaoui et al. (2012) |
| TNBS-induced colitis in rats | 100 | 5 days | BW↑ macroscopic and microscopic colon damage scores↓ inflammation grade↓ | TLR-4↓MyD88↓NF-γB↓MPO↓MDA↓ | Lubbad et al. (2009) |
| DSS-induced colitis in mice | 36.8–92 | 7–14 days | the severity of DSS-induced colitis↓ | STAT3↓CyclinD↓CDK4↓p53↓p21↓ | Yang et al. (2013) |
| Acetic acid–induced colitis in rats | 100 | 12 days | Colon inflammation score↓ BW↑ macroscopic and microscopic colon damage scores↓ | MPO↓MDA↓SOD↓CAT↓MAPK↑ | Topcu-Tarladacalisir et al. (2013) |
| DSS-induced colitis in mice | 50 | 7 days | DAI↓ macroscopic and microscopic colon damage scores↓ | pSTAT↓MPO↓IL-1β↓TNF-α↓ | Liu et al. (2013) |
| TNBS-induced colitis in rats | 30 | 14 days | BW↑ macroscopic and microscopic colon damage scores↓ | MPO↓Th1↓IFN-γ↓Th2↑IL-4↑ | Zhang et al. (2006b) |
| TNBS-induced colitis in rats | 50–100 | 14 days | BW↑ macroscopic and microscopic colon damage scores↓ | MPO↓TNF-α↓COX-2↓iNOS↓p38MAPK↓ | Camacho-Barquero et al. (2007) |
| DSS-induced colitis in rats | 100 | 7 days | Relative colonic weight/length ratio↓ macroscopic and microscopic colon damage scores↓ | TNF-α↓MPO↓NO↓MDA↓GSH↑GST↑ | Arafa et al. (2009) |
| DSS-induced colitis in mice | 15, 30, 60 | 7 days | DAI↓ macroscopic and microscopic colon damage scores↓ | TNF-α↓MPO↓p-p38MAPK↓p38MAPK↓ | Li et al. (2015) |
| DSS-induced colitis in mice | 15, 30, 60 | 7 days | DAI↓ macroscopic and microscopic colon damage scores↓ | TNF-α↓IL-6↓IL-17↓ATG5↓LC-3Ⅱ↓ beclin-1↓autophagosome↓IL-10↑bcl-2↑ | Yue et al. (2019) |
| DSS-induced colitis in mice | 15 | 7 days | DAI↓ macroscopic and microscopic colon damage scores↓ | MPO↓TNF-α↓ | Beloqui et al. (2016) |
| DSS-induced colitis in mice | 36.8–92 | 7 days | DAI↓ the body weight↑ the shortening of colon↓ restored the architecture of the mucosal layer↑ | NF-κB↓STAT3↓COX-2↓iNOS↓ | Yang et al. (2018) |
| DSS-induced colitis in mice | 100 | 7 days | DAI↓ spleen index scores↓ | IL-6↓IL-17↓IL-23↓IL-10↑ | Wei et al. (2021) |
a
BW: body weight, DAI: disease activity index.