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. 2022 Jun 20;13:875865. doi: 10.3389/fendo.2022.875865

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Copyright © 2022 Lopez Ruiz, Ernst, Holz and Stuenkel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Physiological stress response to respiratory arrest in the intact adrenal medulla. (A) Generalized increase in the firing rate of the chromaffin cells was observed at the moment of respiratory arrest due to anesthesia overdose. Shown are the results of an individual experiment. Firing rates from 25 cells were analyzed. The black line corresponds to the average firing rate over time ± SEM (left axis). A normalized firing rate (Z-score) over time for each unit (row) is indicated by the color code (right axis). The baseline period is indicated by the dashed box. (B) Relation between the baseline firing rate and the peak firing rate after respiratory arrest. The combined results from three experiment are presented. The frequency 47 of 48 units increased following respiratory arrest. (C) Denervation virtually abolished the increase in firing rate upon respiratory arrest.