Table 2.
Univariate analysis of 30-day mortality of patients with CRKP and CRAB co-infection.
| Variable | Total (n=103) | non-survivor (n=31) | survivor (n=72) | P value |
|---|---|---|---|---|
| Demographic | ||||
| Age | 58 (17-88) | 62 (27-84) | 58 (17-88) | 0.107 |
| gender | 76 (73.8) | 25 (80.6) | 51 (70.8) | 0.299 |
| Admission to an ICU | 66 (64.1) | 25 (80.6) | 41 (56.9) | 0.021 |
| Total hospital stay, days (median, IQR) | 35 (4-234) | 23 (4-155) | 40 (6-234) | 0.007 |
| History of hospital transfers | 35 (34.0) | 9 (29.0) | 26 (36.1) | 0.487 |
| History of department transfers | 61 (59.2) | 17 (54.8) | 44 (61.1) | 0.552 |
| Baseline disease | ||||
| Diabetes | 13 (12.6) | 5 (16.1) | 8 (11.1) | 0.482 |
| Heart dysfunction | 25 (24.3) | 12 (38.7) | 13 (18.1) | 0.025 |
| Neurologic disease | 44 (42.7) | 10 (32.3) | 34 (47.2) | 0.159 |
| Chronic liver diseases | 17 (16.5) | 6 (19.4) | 11 (15.3) | 0.589 |
| Chronic nephrosis | 16 (15.5) | 7 (22.6) | 9 (12.5) | 0.195 |
| Malignancy | 7 (6.8) | 1 (3.2) | 6 (8.3) | 0.345 |
| Antimicrobial regimens | ||||
| Number of anti-KP drugs, n (%) | ||||
| 1 | 13 (16.7) | 1 (4.8) | 12 (21.1) | |
| ≥2 | 65 (82.3) | 20 (95.2) | 45 (78.9) | 0.087 |
| Appropriate treatments within 3 days | 78 (75.7) | 21 (67.7) | 57 (79.2) | 0.215 |
| Effective treatment | 58 (74.4) | 12 (57.1) | 46 (80.7) | 0.035 |
| Laboratory variables from blood, Mean ± SD | ||||
| WBC (109/L) | 12.49 ± 8.33 | 15.25 ± 10.86 | 11.30 ± 6.71 | 0.073 |
| NEUT (109/L) | 10.64 ± 7.55 | 13.64 ± 10.40 | 9.32 ± 5.46 | 0.038 |
| LY (109/L) | 1.33 ± 2.20 | 1.71 ± 3.89 | 1.18 ± 0.69 | 0.466 |
| NLR | 13.16 ± 13.25 | 17.87 ± 14.41 | 11.09 ± 12.25 | 0.029 |
| MONO (109/L) | 0.68 ± 0.77 | 0.57 ± 0.44 | 0.72 ± 0.87 | 0.35 |
| Hb (g/L) | 89 ± 22 | 84 ± 21 | 91 ± 23 | 0.132 |
| PLT (109/L) | 208 ± 147 | 145 ± 144 | 236 ± 141 | 0.004 |
| PT (sec) | 15.5 ± 3.1 | 17.5 ± 3.8 | 14.5 ± 2.1 | <0.001 |
| APTT (sec) | 41.7 ± 12.9 | 49.1 ± 12.7 | 37.8 ± 11.3 | <0.001 |
| D-dimer (mg/L) | 6.4 ± 5.9 | 6.1 ± 5.5 | 6.6 ± 6.1 | 0.772 |
| Albumin (g/L) | 34.8 ± 5.8 | 33.9 ± 6.8 | 35.2 ± 5.4 | 0.331 |
| A/G | 1.54 ± 0.39 | 1.69 ± 0.44 | 1.48 ± 0.36 | 0.012 |
| ALT (U/L) | 85 ± 150 | 113 ± 249 | 72 ± 73 | 0.381 |
| AST (U/L) | 88 ± 135 | 124 ± 207 | 72 ± 83 | 0.191 |
| AST/ALT | 1.42 ± 1.56 | 1.69 ± 1.33 | 1.31 ± 1.51 | 0.203 |
| LDH (U/L) | 567 ± 804 | 775 ± 1166 | 473 ± 565 | 0.259 |
| CRP (mg/L) | 75.17 ± 74.6 | 122.07 ± 96.40 | 53.67 ± 50.12 | 0.004 |
| Creatinine (umol/L) | 98.1 ± 85.1 | 138.2 ± 98.7 | 81.8 ± 73.6 | 0.009 |
| PCT (ng/mL) | 6.08 ± 15.19 | 15.43 ± 24.26 | 1.65 ± 2.46 | 0.007 |
| IL6 (ng/L) | 242.72 ± 431.18 | 537.58 ± 640.68 | 78.90 ± 111.12 | 0.182 |
| CD4 (cells/μL) | 285 ± 224 | 258 ± 204 | 310 ± 247 | 0.613 |
| CD8 (cells/μL) | 184 ± 173 | 159 ± 150 | 207 ± 196 | 0.542 |
| CD4/CD8 | 2.24 ± 1.64 | 2.29 ± 2.11 | 2.20 ± 0.99 | 0.907 |
Data are expressed as n (%) unless stated otherwise.
CRKP, carbapenem-resistant Klebsiella pneumoniae; CRAB, Carbapenem-resistant Acinetobacter baumannii; IQR, inter-quartile range; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; WBC, white blood cell count; Hb, hemoglobin; PLT, platelet; NEUT, neutrophil; LY, lymphocyte; NLR, neutrophil-to-lymphocyte ratio; MONO, monocytes; A/G, albumin/globulin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, Lactate dehydrogenase; PT, Prothrombin Time; APTT, Activated Partial Thromboplastin Time; PCT, procalcitonin; CRP, C-reactive protein; IL, Interleukin.