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. 2022 Jun 20;12:919414. doi: 10.3389/fcimb.2022.919414

Table 3.

Univariate and multivariate Cox regression analysis of risk factors for 30-day mortality.

Variable Univariate analysis Multivariate analysis
HR 95%CI for HR P value aHRa 95%CI for HR P value
Sex, male vs female 1.61 0.66-3.93 0.295
Age, year, ≥65 vs <65 1.90 0.94-3.85 0.074
Heart dysfunction 2.21 1.07-4.56 0.031
WBC, 109/L, ≥14.3 vs <14.3 3.15 1.53-6.50 0.002
NEUT, 109/L, >11.9vs <11.9 3.37 1.63-6.96 0.001 3.12 1.08-8.98 0.035
NLR, ≥10.3vs <10.3 4.37 1.99-9.58 <0.001
PLT, 109/L, <75 vs ≥75 5.23 2.55-10.75 <0.001
PT, ≥16 vs <16 4.44 2.06-9.56 <0.001
APTT, ≥42 vs <42 4.97 2.19-11.26 <0.001
A/G, ≥1.69 vs <1.69 2.85 1.39-5.85 0.004
CRP, mg/L, ≥149 vs <149 8.34 3.48-19.96 <0.001 4.41 1.45-13.45 0.009
Creatinine, μmol/L, ≥97 vs <97 3.34 1.58-7.09 0.002
PCT, ng/mL, ≥3 vs <3 4.72 2.20-10.16 <0.001
Effective treatment 0.51 0.25-1.05 0.068

aAdjusted hazard ratio for age and sex.

The thresholds for blood tests are based on the cut-off point of the ROC curve.

CI, confidence interval; HR, hazard ratio; WBC, white blood cell count; PLT, platelet; NEUT, neutrophil; NLR, neutrophil-to-lymphocyte ratio; A/G, albumin/globulin; PT, Prothrombin Time; APTT, Activated Partial Thromboplastin Time; PCT, procalcitonin; CRP, C-reactive protein.