Fig. 4.

Plasma R406 concentration after a single oral administration of fostamatinib. Plasma R406 concentrations (ng/mL) in healthy human volunteers after an oral administration of a single dose of 80 mg, 250 mg, and 400 mg of fostamatinib in phase I clinical trial. Blood samples were collected at pre-dose, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, 24, 32, 48, 56, 72, 96, and 120 h after dosing.

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