Table 2.

Drug–drug interactions affected by R406 exposure

Co-administered drugs	Dosage of co-administered drugs (daily)	Dosage of fostamatinib (daily)	Analyte	Geometric mean ratio (90% CI)		References
				AUC	Cmax
Ketoconazole	200 mg twice	80 mg once	R406	2.02 (1.77–2.30)	1.37 (1.23–1.53)	[54, 58]
Verapamil	80 mg three times	150 mg once	R406	1.39 (1.08–1.80)	1.06 (0.78–1.44)	[54, 58]
Rifampicin	600 mg once	150 mg once	R406	0.25 (0.19–0.32)	0.41 (0.30–0.56)	[54, 58]
Rosuvastatin	20 mg once	100 mg twice	R406	1.10 (1.04–1.16)	1.13 (1.02–1.25)	[54, 61, 66]
Simvastatin	40 mg once	100 mg twice	R406	1.11 (1.01–1.22)	1.12 (0.98–1.27)	[54, 61]
Ranitidine	150 mg once	150 mg once	R406	0.97 (0.80–1.18)	0.98 (0.71–1.34)	[49, 54]

AUC area under the plasma concentration–time curve, CI confidence interval, C_max maximum concentration, Ref. references