Table 3.

Effect of fostamatinib drug–drug interactions on co-administered drugs

Co-administered drugs	Dosage of co-administered drugs (daily)	Dosage of fostamatinib (daily)	Analyte	Geometric mean ratio (90% CI)		References
				AUC	Cmax
Microgynon (OC)	Ethinyl estradiol 30 µg once	100 mg twice	Ethinyl estradiol	1.28 (1.22–1.36)	1.34 (1.26–1.43)	[54, 61]
Microgynon (OC)	Levonorgestrel 150 µg once	100 mg twice	Levonorgestrel	1.05 (0.98–1.13)	0.91 (0.90–1.04)	[54, 61]
Pioglitazone	30 mg	100 mg twice	Pioglitazone	1.18 (1.08–1.28)	0.83 (0.64–1.07)	[54, 64]
Digoxin	0.25 mg once	100 mg twice	Digoxin	1.37 (1.30–1.46)	1.70 (1.46–1.98)	[52, 54]
Warfarin	25 mg once	100 mg twice	R-warfarin	1.18 (1.13–1.23)	1.02 (0.97–1.08)	[54, 61]
Warfarin	25 mg once	100 mg twice	S-warfarin	1.13 (1.07–1.19)	0.99 (0.93–1.06)	[54, 61]
Rosuvastatin	20 mg once	100 mg twice	Rosuvastatin	1.95 (1.77–2.15)	1.88 (1.69–2.09)	[54, 61]
Simvastatin	40 mg once	100 mg twice	Simvastatin	1.64 (1.33–2.02)	2.12 (1.64–2.74)	[54, 61]

AUC area under the plasma concentration–time curve, CI confidence interval, C_max maximum concentration, OC oral contraceptive, Ref. references