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. 2022 Jun 20;9:924579. doi: 10.3389/fmed.2022.924579

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Copyright © 2022 Shi, Xiang, Feng, Yang, Li, Fang, Xu, Qi, Shen, Tang, Shen, Wang, Xu and Rao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of N6-methyladenosine (m⁶A)-modified transcript in ureter tissue samples from patients with megaureter (M) or vesicoureteral reflux (VUR, V). (A) The m⁶A peaks' density distribution along the chromosomes. The first (red circle) and second (blue circle) tracks indicate the frequency distribution of the hyper-and hypomethylated peaks, respectively. chr, chromosome. (B) Chromosomal distribution patterns of the hypermethylated (red) and hypomethylated (blue) m6A peaks within mRNAs. (C) Differentially methylated mRNAs based on log2(FC). (D) Differentially expressed mRNAs based on log2(FC).