Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 20;9:924579. doi: 10.3389/fmed.2022.924579

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Shi, Xiang, Feng, Yang, Li, Fang, Xu, Qi, Shen, Tang, Shen, Wang, Xu and Rao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Prediction and function of RNA-binding proteins (RBPs) for N⁶-methyladenosine (m⁶A) methylation. (A) Bubble chart represented as the binding rates of the 140 RBPs. Values were displayed as the differentially methylated mRNAs based on log2(FC). The number of genes binding to the RBPs by prediction was presented by bubble size. (B) Bubble chart showing the binding rates of the known m⁶A readers (YTHDF1, YTHDF2, YTHDC1), m⁶A writers (WTAP, METTL3, METTL14) and eraser ALKBH5 by prediction. (C) Network mapping showing the genes binding to the m⁶A readers, writers and erasers by prediction. (D,E) Enrichment analyses of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) of the 215 candidate RBP genes. (F) Real-time PCR confirmed the mRNA levels of m6A readers (YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3), erasers (FTO and ALKBH5) and writers (WTAP, METTL3, METTL14).