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. 2022 Jun 20;13:882216. doi: 10.3389/fimmu.2022.882216

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Copyright © 2022 Li, Su, Chen, Liu, Zhang, Shen, You, Wang, Zhang, Wang, Wen, Wang, Shao, Chen and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Univariate Cox regression analysis of necroptosis genes in pan-cancer. Grey denotes P>0.05, red represents P<0.05 (HR>1), while blue denotes HR<1. (B) The number of genes with significant Cox analysis in all tumors was counted. The final risk score was determined by adding risk factors (+1) and subtracting protective factors (–1). (C) Survival difference between high and low gene expression groups. The size of the dots represents the significance of the gene’sinfluence on survival for each cancer type, and the statistical significance of differences was determined by cox regression analysis. Red dots represent worse survival and blue dots represent the opposite.