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. 2022 Jun 20;13:882216. doi: 10.3389/fimmu.2022.882216

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Copyright © 2022 Li, Su, Chen, Liu, Zhang, Shen, You, Wang, Zhang, Wang, Wen, Wang, Shao, Chen and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A pie chart representing the proportion of different types of CNV of one gene in one cancer, and different colors represent different types of CNV. Hete Amp = heterozygous amplification; Hete Del = heterozygous deletion; Homo Amp = homozygous amplification; Homo Del = homozygous deletion; None = no CNV. (B) Heterozygous CNV profile, including amplification and deletion percentage for each gene in each cancer. Only genes with >5% CNV in cancers are shown. The size of the point represents the statistical significance, where the bigger the dot size, the higher the statistical significance. FDR, false discovery rate. (C) Homozygous CNV profile, including amplification and deletion percentage for each gene in each cancer. Only genes with >5% CNV in cancers are shown. The size of the point represents the statistical significance, where the bigger the dot size, the higher the statistical significance. FDR, false discovery rate. (D) mRNA expression and CNV data merged by TCGA barcode. The association between paired mRNA expression and CNV percent samples was tested based on Pearson’s product-moment correlation coefficient and follows a t-distribution. The size of the point represents the statistical significance, where the bigger the dot size, the higher the statistical significance. FDR, false discovery rate.