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. 2022 Jun 20;13:882216. doi: 10.3389/fimmu.2022.882216

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Copyright © 2022 Li, Su, Chen, Liu, Zhang, Shen, You, Wang, Zhang, Wang, Wen, Wang, Shao, Chen and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Bar plot showing the biomarker relevance of necroptosis scores compared to standardized cancer immune evasion biomarkers in immune checkpoint blockade (ICB) sub-cohorts. The area under the receiver operating characteristic curve (AUC) was used to assess the predictive efficacy of test biomarkers for determining IBC response to TCGA for different cancer types. (B–D) Patients with high scores exhibit poorer prognostic outcomes after immunotherapy. CR, complete responses; PR, partial responses; PD, progressive disease; SD, stable disease. *P < 0.05, **P < 0.01.