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Hub targets expression. (a) The mRNA expression of EP300, EGFR, TP53, RPS27A, MYC, HSP90AA1, UBC, AKT1, GAPDH, and HSPA8 were detected by the qRT-PCR assay. (b) Western blot was used to detected the protein expression of MYC, EGFR, TP53, and AKT1 targets. ∗P < 0.05, ∗∗P < 0.01 and ∗∗∗P < 0.001 vs. control group; #P < 0.05, and ##P < 0.01 vs. model group; ΔΔP < 0.01, and ΔP < 0.05 vs. low-dose Nux vomica group.
