Figure 4.

Restricted cubic spine curves for the associations between serum soluble α-Klotho and the four specific cardiovascular diseases. Adjusted odds ratio (OR) (solid lines) and 95% confidence intervals (gray shadow) for congestive heart failure (CHF), coronary heart disease, myocardial infarction (MI), and stroke after controlling covariates in Table 1. Spines were examined in the fully adjusted model with the best placed knots at the 5^th, 35^th, 65^th, and 95^th percentiles of α-Klotho concentrations.