Figure 5.

Subgroup analyses of the associations of serum soluble α-Klotho with CHF and MI. Risks of heart failure and MI of the lowest quartile of α-Klotho, as defined by equal to or <646.4 pg/ml, compared to the highest quartile of α-Klotho. The results are expressed as fully adjusted ORs after controlling for covariates, such as age, sex, body mass index, race, education, smoking, drinking, diabetes, hypertension, physical activity, white blood cell counts, neutrophil-to-lymphocyte ratio, platelet counts, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, serum calcium, serum phosphorus, urine albumin, estimated glomerular filtration rate, HbA1c, energy intake, total fat intake, and medications. In addition, possible interactions between the above factors were also adjusted if necessary.