Table 1.

Biomarkers identified by IPA in mouse tumors

Symbol	Entrez gene name	Family	Drug(s)	Expr log ratio	Expr p value	Biomarker application(s)	Diseases (relevant)
ALDH1A1	aldehyde dehydrogenase 1 family member A1	enzyme	disulfiram, chlorpropamide	3.437	0.041	diagnosis and disease progression	cancer, immunological disease, inflammatory disease, inflammatory response, and renal and urological disease
ALDH3A1	aldehyde dehydrogenase 3 family member A1	enzyme		2.577	0.012	diagnosis	cancer, inflammatory disease, and renal and urological disease
CARD9	caspase recruitment domain family member 9	other		3.979	0.000	diagnosis	cancer, inflammatory disease, inflammatory response
CAV1	caveolin 1	receptor		1.839	0.047	diagnosis	cancer
EGFR	epidermal growth factor receptor	kinase	hemay020, cetuximab and erlotinib, CK-101, etc.	2.162	0.043	diagnosis, disease progression, efficacy, prognosis, response to therapy, safety	cancer, immunological disease, inflammatory disease, inflammatory response, and renal and urological disease
ERCC5	ERCC excision repair 5, endonuclease	enzyme		2.105	0.016	diagnosis and response to therapy	cancer, immunological disease, inflammatory disease, inflammatory response, and renal and urological disease
HP	haptoglobin	peptidase		4.224	0.004	diagnosis and efficacy	cancer, immunological disease, inflammatory disease, inflammatory response, and renal and urological disease
IL-23A	interleukin-23 subunit alpha	cytokine	LY3074828, tildrakizumab, and guselkumab	−3.196	0.016	diagnosis	cancer
LGALS7/LGALS7B	galectin 7	other		−5.229	0.005	disease progression	cancer and renal and urological disease
PPL	periplakin	other		2.072	0.049	diagnosis	cancer and renal and urological disease
VEGFD	vascular endothelial growth factor D	growth factor		2.867	0.014	diagnosis, disease progression, efficacy, and prognosis	cancer, hypersensitivity response, immunological disease, inflammatory disease, and inflammatory response