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Immune checkpoint inhibitor and its application on TNBC treatment: (A) Immune checkpoint inhibitors.
| Target | Antibody | Trade name | Isotype | Initial approval time |
|---|---|---|---|---|
| CTLA-4 | Ipilimumab Tremelimumab |
Yervoy / |
IgG1 IgG2 |
2011/325 2015/4/15 |
| PD-1 | Pembrolizumab Nivolumab Cemiplimab |
Keytruda Opdivo Libtayo |
IgG4 IgG4 IgG4 |
2014/9/5 2015/6/22 2021/2/22 |
| PD-L1 | Atezolizumab Avelumab Durvalumab |
Tecentriq Bavencio Imfinzi |
IgG1 IgG1 IgG1 |
2016/5/18 2017/3/23 2017/5/21 |
