TABLE 2.

Plant derived polyphenolic compounds act as prooxidants in the cellular microenvironment of malignant cells: Role of ROS.

Effect	Mechanism
Apoptosis	The c-Met-Nrf2-HO-1 pathway causes apoptotic cell death by increasing cell oxidation Chakraborty et al. (2019)
	Reduced ROS caused by GPx3 expression causes G2/M arrest An et al. (2018)
	ROS increases apoptosis through altering MAPK and AKT signaling, as well as DNA damage-induced p53 phosphorylation (Zhu et al. (2016)
	Increased ROS and substantial cell apoptosis due to nicotinamide nucleotide transhydrogenase knockdown Li et al. (2018a)