Table 2.

In individuals with coronary artery disease (CAD), modern gut microbiota sequencing investigations are being conducted.

Study	(Cui et al., 2017)	(Jie et al., 2017)	(Zhu et al., 2018)
Patients	CAD verified by coronary angiography	CAD verified by coronary angiography	CAD verified by coronary angiography
Patient age	68.3 ± 9.5 years	40-80 years	63.5
Gender% (f/m)	85/15	–	58/42
Sample size	n = 29 CAD n = 35 controls	n = 218 CAD n = 187 controls	n = 70 CAD n = 98 controls
Methods	16 s rRNA	Metagenomics	16 s rRNA
Parallel plasma/serum	No	No	No
Dietary data	No	No	No
Increased relative abundance in patients	-Firmicutes phylum	Enterobacteriaceae family and Streptococcus species	Escherichia-Shigella and Enterococcus
Decreased relative abundance in patients	Bacteroidetes phylum	Roseburia Intestinalis and Faecalibacterium Prausnitzii	Faecalibacterium, Roseburia, Subdoligranulum and Eubacteriumrectale.
Functional findings	–	-Less fermentative capacity and more inflammatory properties in CAD microbiomes	Several predicted functions, including lipopolysaccharide biosynthesis and propanoate metabolism enhanced in CAD microbiomes