FIGURE 3.

Neuroinflammatory mechanisms underlying diabetes-related chronic itch. The mechanical itch induced by MGO or in the STZ-induced mouse model of T1DM is mediated by activation of TRPA1, Nav1.7, and ERK in the DRG neurons. In the T2DM mouse model, the upregulation of P2Y12 expression in SGCs contributes to the increase of ROS, followed by the activation of NLRP3 inflammasome, the upregulation of inflammatory cytokines, and the damage to peripheral nerves. These changes finally result in DRG neuron hyperexcitability and sensitization.