TABLE 4.
Summary of representative localization signals.
| Localization Signal | |||
|---|---|---|---|
| Localization Signal | Location | Sensor Name | References |
| Nuclear export signal (NES) | Cytosol | EKAREV | Komatsu et al. (2011) |
| Nuclear localization signal (NLS) | Nuclear | JNKAR1EV-NLS | Kim et al. (2020) |
| Histone H3 | Histone H3 | H3K9me3 Biosensor | Peng et al. (2018) |
| Mitochondrial targeting sequence (MTS) | Mitochondrial matrix | mito-ZifCY1.173 | Park et al. (2012) |
| C-terminal sequence of Bcl-xl | Mitochondrial outer membrane | Daglas-mit1 | Sato et al. (2006) |
| Leader sequence from the second mitochondria derived activator of caspases (SMAC) | Mitochondrial intermembrane region | SMAC-mCherry-GZnP2 | Fudge et al. (2018) |
| Lyn acylation substrate sequences | Lipid raft | Lyn-Src biosensor | Seong et al. (2009) |
| K-Ras prenylation sequences | Nonraft | Kras-Src biosensor | Seong et al. (2009) |
| PH and PTB domain of IRS-1 | IRS-1 | Phocus-2ppnes | Sato et al. (2002) |
| Igκ-chain leader sequence and PDGFR transmembrane domain | Extracellular region | MT1-MMP biosensor | Ouyang et al. (2008) |
| eNOS targeting domain | Golgi apparatus | eNOS-Aktus | Sasaki et al. (2003) |
| Calreticulin signal sequence (CRsig) and ER retention sequence (KDEL) | Endoplasmic reticulum (ER) | ER Ca2+ sensor | Kim et al. (2017) |