Table 1.
Comparison of hemodynamic variables at baseline, acute period, and compensation period in a dog model of acute pulmonary embolism.
| Baseline | Acute period | Compensation period | |||
|---|---|---|---|---|---|
| value | value | P | value | P | |
| Heart rate (beat/min) | 110 (101–117) | 102 (95–111) | 0.51 | 106 (103–111) | 0.92 |
| Mean BP (mmHg) | 58 (56–59) | 47 (44–54)* | 0.006 | 51 (48–58) | 0.19 |
| Systolic PAP (mmHg) | 15 (14–18) | 26 (23–27)* | <0.001 | 26 (24–29) * | <0.001 |
| Mean PAP (mmHg) | 12 (10–14) | 23 (21–24)* | <0.001 | 24 (20–25)* | <0.001 |
| Diastolic PAP (mmHg) | 10 (7–11) | 19 (17–20)* | <0.001 | 20 (15–21)* | <0.001 |
| Mean RVP (mmHg) | 9 (7–11) | 14 (12–17)* | 0.019 | 13 (10–13) | 0.28 |
| Mean CVP (mmHg) | 2 (1–2) | 4 (3–6)* | 0.016 | 2 (1–3) | 0.98 |
| Mean PAWP (mmHg) | 6 (4–6) | 5 (4–7) | 0.81 | 5 (2–7) | 0.81 |
| CI (L/min/m2) | 4.4 (3.5–4.4) | 2.8 (2.6–3.7) | 0.085 | 4.1 (3.6–5.2) | 0.90 |
| Max dP/dt (mmHg/sec) | 117 (107–148) | 173 (141–195) | 0.16 | 201 (146–255)* | 0.016 |
| PVR (WU) | 3.1 (2.9–3.4) | 10.5 (7.8–13.4)* | <0.001 | 8.5 (6.1–9.9)* | 0.002 |
| SVR (WU) | 26.1 (22.1–29.9) | 26.1 (23.1–30.5) | 0.43 | 24.9 (20.9–26.4) | 0.62 |
| Rp/Rs | 0.12 (0.11–0.14) | 0.36 (0.33–0.50)* | <0.001 | 0.36 (0.30–0.41)* | <0.001 |
Continuous variables were displayed as median (interquartile range). BP, Blood pressure; PAP, Pulmonary arterial pressure; RVP, Right ventricular pressure; CVP, Central venous pressure; PAWP, Pulmonary artery wedge pressure; CI, Cardiac index; Max dP/dt, Maximum positive rate of RV pressure change; PVR, Pulmonary vascular resistance; SVR, Systemic vascular resistance; Rp/Rs, PVR to SVR ratio. *P < 0.05 compared with the baseline.