Table 1.
Studies characteristics.
| N | Author and year | Type of study | N. patients | Target | Dose for fraction (fr) | Time interval during/after RT | Toxicity |
|---|---|---|---|---|---|---|---|
| 1 | Binitha 2014 | Case report | 1 | Hypopharynx | 60 Gy for 26 days | 9 years | Multipl hemorrhagic bullae and erosions, with a few vesicles, were present on the dorsum of the right hand and fingers, and the anterior aspect of the right leg and ankle. Erosion in Oral cavity. |
| 2 | Trombetta 2015 | Case report | 1 | Breast | 4256 cGy at 266 cGy per fraction | 2 months | Tenderness and erythema in the breast near the areola |
| 3 | Nieder 2015 | Case report | 1 | Mediastinal and left-sided axillary lymph node metastases | 30 Gy in 10 fr | During RT | Bullous pemphigoid mainly involving trunk and arms |
| 4 | Campa 2016 | Case report | 1 | Partial breast | 34 Gy Brachyterapy | 5 months | Painful, pruritic, erythematous rash on her left breast with erosions and vesicles containing cloudy and clear fluid |
| 5 | Shon 2016 | Cases series | 2 | - Cervical squamous carcinoma; - Squamous cell carcinoma of unknown origin on the neck |
/ / | 9 months 6 motnhs | - Generalized pruritic rash of 1 month’s duration and occasional blistering without mucosal involvement - A blistering eruption that had developed on the neck, the upper part of the chest, and other body sites, including the oral mucosa |
| 6 | Kluger 2016 | Case report | 1 | Breast | 40.05 Gy in 2.67 fractions | Less than a month | Itchy vesicles and blisters appeared on the right breast and led to larger hemorrhagic blisters and erosions, on the extremities with a gloves and socks disposition. |
| 7 | Hirotsu 2017 | Case report | 1 | Pelvic nodal metastases | 48 Gy | 3 weeks | Tense bullae localized to the right thigh within the recent radiation treatment field |
| 8 | Tanita 2018 | Case report | 1 | Second cervical vertebra | 45 Gy in 5 fractions | 7 weeks | Large, tense bullae and erosion aris- ing on erythematous plaque on the trunk and extremities |
| 9 | Grimaux 2018 | Case report | 1 | Costal metastases | 30 Gy in 10 fractions | A few hours after the first session | Small pruritic blisters appeared over left hemi-thorax. These progressed to very large postbullous mucosal erosions |
| 10 | Hung 2019 | Case–control study | 196* | 90 breast 110 others | / | / | / |
| 11 | Kim 2020 | Case report | 1 | Whole-pelvis and whole- brain radiotherapy for 3 months | / | 8 months | Bullae and erosion in the right thigh |
| 12 | Rejeb 2020 | Case report | 1 | Breast cancer | 50 Gy/25 fractions | 2 months | Erythematous and pruritic vesicular eruption developed initially in the irradiated area and extended later on over other skin areas |
| 13 | Palleschi 2020 | Case report | 1 | Laryngeal cancer | / | 6 years | Multiple areas of blisters, erosions, and pseudomembranes on the epiglottis and |