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. 2022 Jun 20;13:923945. doi: 10.3389/fphys.2022.923945

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Copyright © 2022 Darquenne, Borojeni, Colebank, Forest, Madas, Tawhai and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic outline of the production, transport and fate of respiratory droplets among individuals as addressed in this article. (A) Exhaled breath and aerosol dynamics (Section 2). (B) Fate of inhaled aerosols in the respiratory system (Section 3). (C) Fate of inhaled infectious aerosols deposited at the air-airway surface liquid interface (Section 4). (D) Particle distribution effect on viral binding, importance of local dose versus averages over the whole lung (Section 5). (E) Endothelial dysfunction and pulmonary circulatory interactions with SARS-CoV-2 (Section 6). (F) Linking personalized models to population models (Section 7).