Fig. 6.

Abnormal thalamocortical connectivity to the Rolandic cortex in Rolandic epilepsy (A) The Rolandic cortex and thalamus (green) were used as seed and target ROIs in each analysis. (B) Control children have increased functional connectivity from the thalamus to the Rolandic cortex with age (p = 0.02). In contrast, there is no evidence of a relationship between age and functional connectivity from the thalamus to the Rolandic cortex in children with active (p = 0.2) or resolved Rolandic epilepsy (blue, p = 0.5). (C) Control children have a trend toward increased structural connectivity from the thalamus to the Rolandic cortex with age (p = 0.052). In contrast, there is no evidence of a relationship between age and structural connectivity from the thalamus to the Rolandic cortex in children with active (p = 0.6) or resolved Rolandic epilepsy (p = 0.2).