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. 2022 Jun 21;66(3):3391. doi: 10.4081/ejh.2022.3391

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Figure 7. — Western-style diet assumption in NAFLD/NASH was accompanied by cellular senescence, characterized by the arrest of the cell cycle in the G¹/S phase, and by an increase in levels of several molecules (β-Gal, pH2aX, and the SASP: IL-6, MMP1). NAFLD/NASH is also associated with iron deposition in the liver parenchyma and concomitantl increased Gpx4 expression, leading to ferroptosis resistance. These mechanisms can co-occur in the same cell, cooperating to exacerbate NAFLD/NASH progression.