Intervention(s) and comparator(s)	Duration of intervention (duration of follow‐up)	Participating population	Study period [year to year]	Country	Setting	Ethnic groups [%]	Duration of condition [mean/range years (SD), or as reported]
Hero 2005	I: letrozole	2 years (2 years)	Prepubertal and pubertal males with ISS	2001‐2004	Finland	OPD	‐	‐
	C: placebo
Mauras 2008	I: anastrozole + GH	12‐36 months (12‐36 months)	Pubertal males with GH deficiency	‐	USA	OPD	‐	Minimum 6 months on GH
	C: placebo + GH
Salehpour 2010	I1: letrozole	2 years (2 years)	Males with CDGP and short stature	‐	Iran	OPD	‐	‐
	I2: oxandrolone
	C: placebo
Wickman 2001	I: letrozole + testosterone	12 months (18 months)	Males with CDGP	1998‐2000	Finland	OPD	‐	‐
	C1: placebo + testosterone
	C2: no treatment
"‐" denotes not reported C: control; CDGP: constitutional delay of growth and puberty; GH: growth hormone; I: intervention; ISS: idiopathic short stature; OPD: outpatient department; SD: standard deviation