Outcome	High risk of bias (category A)a	High risk of bias (category D)b	High risk of bias (category E)c	High risk of bias (category G)d
Salehpour 2010	Adverse events	x	‐	‐	‐
Wickman 2001	Adverse events	‐	‐	‐	x
	Bone density	x	‐	‐	‐
aClear that outcome was measured and analysed; trial report stated that outcome was analysed but only reported that result was not significant (Classification 'A', table 2, Kirkham 2010) bClear that outcome was measured and analysed; trial report stated that outcome was analysed but no results reported (Classification 'D', table 2, Kirkham 2010) cClear that outcome was measured but not necessarily analysed; judgement says likely to have been analysed but not reported because of non‐significant results (Classification 'E', table 2, Kirkham 2010) dUnclear whether the outcome was measured; not mentioned but clinical judgement says likely to have been measured and analysed but not reported on the basis of non‐significant results (Classification 'G', table 2, Kirkham 2010)